abstract：OBJECTIVE:Our purpose was to determine whether the use of catechol-O-methyltransferase-inhibitors (ICOMT) can reduce the risk of developing levodopa (LD)-induced neuropathy in Parkinson's disease (PD) patients. METHODS:A multicentre study of 197 PD patients was performed. 144 were exposed to LD for more than three yea...

journal_title：Parkinsonism & related disorders

authors： Cossu G,Ceravolo R,Zibetti M,Arca R,Ricchi V,Paribello A,Murgia D,Merola A,Romagnolo A,Nicoletti V,Palermo G,Mereu A,Lopiano L,Melis M,Abbruzzese G,Bonuccelli U

更新日期：2016-06-01 00:00:00

abstract：INTRODUCTION:The aim of this study was to examine the association between mild parkinsonian signs (MPS), cerebral small-vessel disease (SVD), and total SVD burden in patients with vascular risk factors. METHODS:We performed a cross-sectional study among 268 patients with vascular risk factors but without parkinsonism ...

journal_title：Parkinsonism & related disorders

authors： Hatate J,Miwa K,Matsumoto M,Sasaki T,Yagita Y,Sakaguchi M,Kitagawa K,Mochizuki H

更新日期：2016-05-01 00:00:00

abstract：INTRODUCTION:The sonographic appearance of the substantia nigra is abnormally bright and enlarged (hyperechogenic) in young adults with a history of illicit stimulant use. The abnormality is a risk factor for Parkinson's disease. The aim of the current study was to identify the type of illicit stimulant drug associated...

journal_title：Parkinsonism & related disorders

authors： Todd G,Pearson-Dennett V,Wilcox RA,Chau MT,Thoirs K,Thewlis D,Vogel AP,White JM

更新日期：2016-04-01 00:00:00

abstract：INTRODUCTION:It is well known that α-synuclein (SNCA) and microtubule associated protein (MAPT) genes predispose individuals to develop Parkinson's disease (PD). However, whether these genes contribute to differences in the variable progression observed in PD is obscure. This study aims to evaluate the association of c...

journal_title：Parkinsonism & related disorders

authors： Wang G,Huang Y,Chen W,Chen S,Wang Y,Xiao Q,Liu J,Fung VS,Halliday G,Chen S

更新日期：2016-03-01 00:00:00

abstract：OBJECTIVES:Dissatisfaction with subthalamic deep brain stimulation (STN-DBS) despite motor improvements has been observed in Parkinson's disease (PD). Hence, we compared patient's subjective perceived outcome 12 months after surgery (12mFU) with clinical measures to identify risk factors of dissatisfaction. METHODS:Pa...

journal_title：Parkinsonism & related disorders

authors： Maier F,Lewis CJ,Horstkoetter N,Eggers C,Dembek TA,Visser-Vandewalle V,Kuhn J,Zurowski M,Moro E,Woopen C,Timmermann L

更新日期：2016-03-01 00:00:00

abstract：BACKGROUND:Many patients with advanced Parkinson's disease (PD) are reluctant to undergo the subthalamic nucleus deep brain stimulation (STN-DBS) when surgery is warranted. Reasons for this reluctance have not been examined. We undertook to establish the rate and causes of this reluctance for STN-DBS in patients with a...

journal_title：Parkinsonism & related disorders

authors： Kim MR,Yun JY,Jeon B,Lim YH,Kim KR,Yang HJ,Paek SH

更新日期：2016-02-01 00:00:00

abstract：INTRODUCTION:Mutations in GNAL have been associated with adult-onset cranio-cervical dystonia, but a limited number of cases have been reported so far and the clinical spectrum associated with this gene still needs to be fully characterized. METHODS:We identified an Italian family with adult-onset, dominantly-inherite...

journal_title：Parkinsonism & related disorders

authors： Carecchio M,Panteghini C,Reale C,Barzaghi C,Monti V,Romito L,Sasanelli F,Garavaglia B

更新日期：2016-02-01 00:00:00

abstract：BACKGROUND:Motor complications may become major challenges in the management of patients with Parkinson's disease. In this study, we sought to determine the incidence, risk factors, evolution, and treatment of motor fluctuations and dyskinesias in a population-representative, incident Parkinson's disease cohort. METHO...

journal_title：Parkinsonism & related disorders

authors： Bjornestad A,Forsaa EB,Pedersen KF,Tysnes OB,Larsen JP,Alves G

更新日期：2016-01-01 00:00:00

abstract：INTRODUCTION:Olfactory dysfunction and neuropsychological symptoms like depression and anhedonia are common non-motor symptoms in Parkinson's disease (PD). The assessment of both functional domains includes clinical examination, olfactory testing, and standardized questionnaires. While olfaction is readily assessed by ...

journal_title：Parkinsonism & related disorders

authors： Mrochen A,Marxreiter F,Kohl Z,Schlachetzki J,Renner B,Schenk T,Winkler J,Klucken J

更新日期：2016-01-01 00:00:00

abstract：:Abnormally aggregated tau protein is central to the pathophysiology of Alzheimer's disease, frontotemporal dementia variants, progressive supranuclear palsy, corticobasal degeneration and chronic traumatic encephalopathy. The post-mortem cortical density of hyperphosphorylated tau tangles correlates with pre-morbid co...

journal_title：Parkinsonism & related disorders

authors： Dani M,Edison P,Brooks DJ

更新日期：2016-01-01 00:00:00

abstract：BACKGROUND:In late stage Parkinson patients there is an unmet need for new treatments to adequately control motor complications, especially dyskinesias. In several preliminary studies, it has been suggested that applying unilateral low-frequency repetitive transcranial magnetic stimulation (LF rTMS), delivered at the p...

journal_title：Parkinsonism & related disorders

authors： Flamez A,Cordenier A,De Raedt S,Michiels V,Smetcoren S,Van Merhaegen-Wieleman A,Parys E,De Keyser J,Baeken C

更新日期：2016-01-01 00:00:00

abstract：:The mild cognitive impairment (MCI) concept was developed to identify the earliest stages of cognitive impairment. MCI and, more specifically, amnestic MCI were initially proposed as transitional states that ultimately progress to full blown Alzheimer's disease (AD). However, MCI subjects do not uniformly progress to ...

journal_title：Parkinsonism & related disorders

authors： Korczyn AD

更新日期：2016-01-01 00:00:00

abstract：:Non motor symptoms (NMS) represent a significant burden in Parkinson's disease (PD) with numerous studies highlighting the importance of NMS both in "pre-motor" phase of PD as well as throughout the course of disease. In part this has led the international Parkinson and Movement Disorder Society (IPMDS) task force to ...

journal_title：Parkinsonism & related disorders

authors： Sauerbier A,Jenner P,Todorova A,Chaudhuri KR

更新日期：2016-01-01 00:00:00

abstract：BACKGROUND:Hyposmia is a common non-motor symptom in Parkinson's disease (PD). However, patients with PD are sometimes unaware of their olfactory dysfunction, resulting in an under-diagnosis of this symptom. To determine whether the loss of awareness of hyposmia results from cognitive impairment in patients with PD, we...

journal_title：Parkinsonism & related disorders

authors： Kawasaki I,Baba T,Takeda A,Mori E

更新日期：2016-01-01 00:00:00

abstract：PURPOSE:The young-onset subtype of Parkinson's disease (YOPD) differs from the late-onset subtype (LOPD) in drug responsiveness, incidence of motor complications, and prognosis. The pathophysiology underlying these differences remains largely unknown. This study investigated whether the two subtypes differ in the patte...

journal_title：Parkinsonism & related disorders

authors： Liu SY,Wu JJ,Zhao J,Huang SF,Wang YX,Ge JJ,Wu P,Zuo CT,Ding ZT,Wang J

更新日期：2015-12-01 00:00:00

abstract：BACKGROUND:Impulse control disorders in Parkinson's disease are a potential consequence of dopaminergic therapy. Impulse control problems might be revealed by intertemporal choice tasks which entail to forgo an immediately available reward in favor of a larger but later reward. The steepness of the discounting curve ca...

journal_title：Parkinsonism & related disorders

authors： Al-Khaled M,Heldmann M,Bolstorff I,Hagenah J,Münte TF

更新日期：2015-11-01 00:00:00

abstract：BACKGROUND:In addition to the most frequent TOR1A/DYT1 mutation (c.907_909delGAG), a growing number of TOR1A sequence variants are found in dystonia patients. For most, functional characterization has demonstrated pathogenicity at different levels, implying that TOR1A genetic testing should not be limited to screening ...

journal_title：Parkinsonism & related disorders

authors： Dobričić V,Kresojević N,Žarković M,Tomić A,Marjanović A,Westenberger A,Cvetković D,Svetel M,Novaković I,Kostić VS

更新日期：2015-10-01 00:00:00

abstract：INTRODUCTION:Inconsistent results regarding the association between the components of metabolic syndrome and Parkinson's disease (PD) have been reported. We investigated whether the metabolic syndrome or its components, or serum total cholesterol, predict PD incidence in a prospective cohort study design. METHODS:The ...

journal_title：Parkinsonism & related disorders

authors： Sääksjärvi K,Knekt P,Männistö S,Lyytinen J,Heliövaara M

更新日期：2015-10-01 00:00:00

abstract：BACKGROUND:The Vanderbilt pilot trial of deep brain stimulation (DBS) in early Parkinson's disease (PD) enrolled patients on medications six months to four years without motor fluctuations or dyskinesias. We conducted a patient-centered analysis based on clinically important worsening of motor symptoms and complication...

journal_title：Parkinsonism & related disorders

authors： Hacker ML,Tonascia J,Turchan M,Currie A,Heusinkveld L,Konrad PE,Davis TL,Neimat JS,Phibbs FT,Hedera P,Wang L,Shi Y,Shade DM,Sternberg AL,Drye LT,Charles D

更新日期：2015-10-01 00:00:00

abstract：OBJECTIVE:The primary objective was to evaluate the efficacy and safety of droxidopa as add-on therapy in improving stiffness, tremors and other motor functions and activities of daily living for moderate-to-severe Parkinson's disease (PD). METHODS:PD patients, above Hoehn-Yahr III (including Hoehn-Yahr III), were ran...

journal_title：Parkinsonism & related disorders

authors： Zhao S,Cheng R,Zheng J,Li Q,Wang J,Fan W,Zhang L,Zhang Y,Li H,Liu S

更新日期：2015-10-01 00:00:00

abstract：INTRODUCTION:Germline silencing of the PD-related protein LRRK2 does not alter glutamate or dopamine release in adult mice, but some exploratory abnormalities have been reported with ageing. Contrastingly, high levels of human LRRK2 cause locomotor alterations and cognitive deficits accompanied by reduced striatal dopa...

journal_title：Parkinsonism & related disorders

authors： Volta M,Cataldi S,Beccano-Kelly D,Munsie L,Tatarnikov I,Chou P,Bergeron S,Mitchell E,Lim R,Khinda J,Lloret A,Bennett CF,Paradiso C,Morari M,Farrer MJ,Milnerwood AJ

更新日期：2015-10-01 00:00:00

abstract：OBJECTIVE:Invasive techniques such as in-vivo microdialysis provide the opportunity to directly assess neurotransmitter levels in subcortical brain areas. METHODS:Five male Filipino patients (mean age 42.4, range 34-52 years) with severe X-linked dystonia-parkinsonism underwent bilateral implantation of deep brain lea...

journal_title：Parkinsonism & related disorders

authors： Tronnier VM,Domingo A,Moll CK,Rasche D,Mohr C,Rosales R,Capetian P,Jamora RD,Lee LV,Münchau A,Diesta CC,Tadic V,Klein C,Brüggemann N,Moser A

更新日期：2015-08-01 00:00:00

abstract：INTRODUCTION:Continuous infusion of levodopa/carbidopa intestinal gel (LCIG) is an effective treatment for patients with advanced Parkinson Disease (PD) that cannot be further improved by oral therapy. METHODS:We conducted an observational, prospective, and multicenter study to collect, in a large sample of PD treated...

journal_title：Parkinsonism & related disorders

authors： Buongiorno M,Antonelli F,Cámara A,Puente V,de Fabregues-Nebot O,Hernandez-Vara J,Calopa M,Pascual-Sedano B,Campolongo A,Valldeoriola F,Tolosa E,Kulisevsky J,Martí MJ

更新日期：2015-08-01 00:00:00

abstract：INTRODUCTION:somatosensory temporal discrimination threshold (STDT) measures the ability to perceive two stimuli as being sequential. Altered STDT has been reported in Parkinson's disease (PD). The cerebellum seems to play a role in the pathophysiology of PD, and may consequently be involved in the pathophysiology of S...

journal_title：Parkinsonism & related disorders

authors： Di Biasio F,Conte A,Bologna M,Iezzi E,Rocchi L,Modugno N,Berardelli A

更新日期：2015-07-01 00:00:00

abstract：BACKGROUND:Tremor-related quality of life is a multi-dimensional concept that reflects the physical, emotional and other health effects of tremor. Curiously, tremor-related quality of life has never been directly compared in patients with the two major tremor disorders, essential tremor (ET) and Parkinson's disease (PD...

journal_title：Parkinsonism & related disorders

authors： Louis ED,Machado DG

更新日期：2015-07-01 00:00:00

abstract：BACKGROUND:Parkinson disease (PD) and multiple system atrophy (MSA) share some neuropathologic features (nigrostriatal dopaminergic lesion, alpha-synuclein deposition) but not others (Lewy bodies in PD, glial cytoplasmic inclusions in MSA). In PD evidence has accrued for a vesicular storage defect and decreased aldehyd...

journal_title：Parkinsonism & related disorders

authors： Goldstein DS,Sullivan P,Holmes C,Kopin IJ,Sharabi Y,Mash DC

更新日期：2015-06-01 00:00:00

abstract：INTRODUCTION:Deep brain stimulation of subthalamic nucleus (STN-DBS) for Parkinson's disease allows for a reduction in medication dosage. Changes in total levodopa equivalent daily dose (LEDD) have been frequently reported, there is little information about changes within the drug classes. METHODS:We retrospectively a...

journal_title：Parkinsonism & related disorders

authors： Alexoudi A,Shalash A,Knudsen K,Witt K,Mehdorn M,Volkmann J,Deuschl G

更新日期：2015-06-01 00:00:00

abstract：INTRODUCTION:In Parkinson's disease (PD), neuropsychiatric symptoms (NPS) can be particularly burdensome for caregivers. The main goal of this study was to assess the impact of NPS, assessed by means of a new specific scale, on caregiver burden. METHODS:A sample of 584 pairs of PD patients and their primary caregivers...

journal_title：Parkinsonism & related disorders

authors： Martinez-Martin P,Rodriguez-Blazquez C,Forjaz MJ,Frades-Payo B,Agüera-Ortiz L,Weintraub D,Riesco A,Kurtis MM,Chaudhuri KR

更新日期：2015-06-01 00:00:00

abstract：INTRODUCTION:To overcome travel distance and lack of local expertise, telemedicine programs have been implemented and are still pilot programs in many jurisdictions. Patient perspectives remain poorly understood. In the largest study to date, we examined user satisfaction and predictors of patient choice to use telemed...

journal_title：Parkinsonism & related disorders

authors： Qiang JK,Marras C

更新日期：2015-05-01 00:00:00

abstract：BACKGROUND:Sleep disorders occur commonly in Parkinson's disease and are often under-recognized and under treated in clinical practice. OBJECTIVES:To determine the quality of sleep in patients with Young onset Parkinson's disease (YOPD) and to note whether there is any difference in quality of sleep from those patient...

journal_title：Parkinsonism & related disorders

authors： Mahale R,Yadav R,Pal PK

更新日期：2015-05-01 00:00:00

abstract：OBJECTIVE:To evaluate the efficacy of solifenacin succinate in Parkinson's disease (PD) patients suffering from overactive bladder (OAB). BACKGROUND:Urinary dysfunction is a commonly encountered non-motor feature in PD that significantly impacts patient quality of life. DESIGN/METHODS:This was a double-blind, randomi...

journal_title：Parkinsonism & related disorders

authors： Zesiewicz TA,Evatt M,Vaughan CP,Jahan I,Singer C,Ordorica R,Salemi JL,Shaw JD,Sullivan KL,Non-Motor Working Group of the Parkinson Study Group (PSG).

更新日期：2015-05-01 00:00:00

abstract：INTRODUCTION:Cerebellar circuits are hypothesized to play a central role in the pathogenesis of essential tremor. Rhythmic finger tapping is known to strongly engage the cerebellar motor circuitry. We characterize cerebellar and, more specifically, dentate nucleus function, and neural correlates of cerebellar output in...

journal_title：Parkinsonism & related disorders

authors： Buijink AW,Broersma M,van der Stouwe AM,van Wingen GA,Groot PF,Speelman JD,Maurits NM,van Rootselaar AF

更新日期：2015-04-01 00:00:00

abstract：BACKGROUND:We developed a novel secured web-based dystonia video repository for the Dystonia Coalition, part of the Rare Disease Clinical Research network funded by the Office of Rare Diseases Research and the National Institute of Neurological Disorders and Stroke. A critical component of phenotypic data collection fo...

journal_title：Parkinsonism & related disorders

authors： Yan L,Hicks M,Winslow K,Comella C,Ludlow C,Jinnah HA,Rosen AR,Wright L,Galpern WR,Perlmutter JS

更新日期：2015-04-01 00:00:00

abstract：BACKGROUND:Deep brain stimulation (DBS) is a well-established treatment for Parkinson's disease (PD). Optimization of DBS settings can be a challenge due to the number of variables that must be considered, including presence of multiple motor signs, side effects, and battery life. METHODS:Nine PD subjects visited the ...

journal_title：Parkinsonism & related disorders

authors： Pulliam CL,Heldman DA,Orcutt TH,Mera TO,Giuffrida JP,Vitek JL

更新日期：2015-04-01 00:00:00

abstract：BACKGROUND:The prevalence and clinical correlates of drooling in Chinese patients with Parkinson disease (PD) are unknown. METHODS:A cross-sectional analysis of 518 Chinese patients with PD was conducted. Assessments included Unified PD Rating Scale (UPDRS), Non-Motor Symptoms Scale (NMSS), Hamilton Depression Scale (...

journal_title：Parkinsonism & related disorders

authors： Ou R,Guo X,Wei Q,Cao B,Yang J,Song W,Shao N,Zhao B,Chen X,Shang H

更新日期：2015-03-01 00:00:00

abstract：INTRODUCTION:Huntington's disease (HD) is the most common hereditary neurodegenerative disorder. Despite the fact that both the gene and the mutation causing this monogenetic disorder were identified more than 20 years ago, disease-modifying therapies for HD have not yet been established. REVIEW:While intense preclini...

journal_title：Parkinsonism & related disorders

authors： Zielonka D,Mielcarek M,Landwehrmeyer GB

更新日期：2015-03-01 00:00:00

abstract：INTRODUCTION:The patho-physiological basis for finger dexterity deficits in Parkinson's disease (PD) is controversial. Previously, bradykinesia was regarded as the major mechanism. However, recent research suggested limb-kinetic apraxia as an important component of impaired fine motor skills in PD. In contrast to brady...

journal_title：Parkinsonism & related disorders

authors： Foki T,Pirker W,Geißler A,Haubenberger D,Hilbert M,Hoellinger I,Wurnig M,Rath J,Lehrner J,Matt E,Fischmeister F,Trattnig S,Auff E,Beisteiner R

更新日期：2015-03-01 00:00:00

abstract：OBJECTIVE:We report a prospective, open label study of 24 h levodopa-carbidopa intestinal gel (LCIG) as treatment for levodopa "unresponsive" freezing of gait (FOG) associated with Parkinson's disease. METHOD:5 patients with disabling FOG, documented as being levodopa "unresponsive", were commenced on continuous 24 h ...

journal_title：Parkinsonism & related disorders

authors： Chang FC,Tsui DS,Mahant N,Wolfe N,Kim SD,Ha AD,Drury M,Griffith JM,Fung VS

更新日期：2015-03-01 00:00:00

abstract：BACKGROUND:Visual hallucinations are an important non-motor complication of Parkinson's disease (PD) and carry a negative prognosis. Their biological basis is uncertain, but may relate to the activity of resting state networks in brain. We therefore aimed to investigate functional activity of brain in patients with vis...

journal_title：Parkinsonism & related disorders

authors： Yao N,Pang S,Cheung C,Chang RS,Lau KK,Suckling J,Yu K,Mak HK,McAlonan G,Ho SL,Chua SE

更新日期：2015-02-01 00:00:00

abstract：INTRODUCTION:Post-operative programming of deep brain stimulation for movement disorders can be both time consuming and difficult, which can delay the optimal symptom control for the patient. Probabilistic maps of stimulation response could improve programming efficiency and optimization. METHODS:The clinically select...

journal_title：Parkinsonism & related disorders

authors： Phibbs FT,Pallavaram S,Tolleson C,D'Haese PF,Dawant BM

更新日期：2014-12-01 00:00:00